Structure and transport mechanism of P5B-ATPases

Structure and transport mechanism of P5B-ATPases

Blog Article

In human cells, P5B‐ATPases execute export of spermine from lysosomes to the cytosol, Nutritionals - Standard Tube Feeding but the mechanisms of spermine recognition, uptake and transport remain elusive.Here the authors present cryo‐EM structures of a yeast homolog of human ATP13A2‐5, Ypk9, which depict three separate Powder Bronzers transport cycle intermediates, including spermine‐bound conformations.